Δευτέρα 4 Απριλίου 2016

The malady of penicillin allergy

Penicillin allergy is a malady that has only recently been fully appreciated. When patients who furnish a history of allergy to penicillin or a penicillin-like drug require antibiotic administration for infection or surgical prophylaxis, an alternative non–β-lactam antibiotic (eg, a carbapenem, a quinolone, a macrolide, or vancomycin) is commonly prescribed. These alternative agents can be associated with greater cost, heightened risk for untoward effects, and increased rates of resistant nosocomial organisms, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, as well as greater risk for developing Clostridium difficile.

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