Comparative assessment of ibuprofen and etodolac in edema, trismus and pain in lower third molar surgery: A randomized, clinical trial

Publication date: Available online 13 April 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Júlio César Silva de Oliveira, Gustavo Augusto Grossi de Oliveira, Ana Paula Farnezi Bassi
PurposeTo compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus following extraction of lower-third molars.MethodsTwenty young adults with two impacted "mandibular-third" molars (in similar positions) were selected for the study. Patients were randomly assigned either to the IBU group (IBU: 600 mg three times a day for 3 days) or to the ETO group (ETO: 300 mg three times a day for 3 days). Drugs were administered immediately following dental extraction.ResultsDuring the first 2 days following extraction, swelling was more pronounced in the IBU group than in the ETO group (p = 0.033). Seven days after surgery, there was no difference in the degree of edema in both groups. At the 2- and 7-day evaluation points, mouth opening was significantly more reduced in the IBU group than that in the ETO group (p < 0.05). After the first 6 h, the ETO group experienced more effective pain relief (p < 0.05), but after this time point both groups reported similar degrees of relief. Compared to the IBU group, the ETO group had lower need for administration of additional rescue analgesics.ConclusionFollowing extraction of impacted lower-third molars, we found that swelling, trismus, and pain, were more effectively controlled with ETO than with IBU.



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