Ultrastructural evaluation of gingival connective tissue in hereditary gingival fibromatosis

Publication date: Available online 16 April 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Sabina Pena B. Pêgo, Paulo Rogério de Faria, Luis Antônio N. Santos, Ricardo D. Coletta, Sibele Nascimento de Aquino, Hercílio Martelli-Júnior
ObjectiveTo describe the ultrastructural features of hereditary gingival fibromatosis (HGF)-affected family members and compare these microscopic findings with normal gingival tissue (NG).Study DesignGingival tissue from 9 HGF patients belonging to five unrelated families was evaluated by transmission electron microscopy. Nine NG tissue samples were used for comparison.ResultsAreas containing collagen fibrils forming loops and folds were observed in both groups, whereas oxytalan fibres were frequently identified in the HGF group. Collagen fibrils' diameter and the interfibrillar space among them were more uniform in the NG group than the HGF group. Fibroblasts were the most common cells found in both the HGF and NG groups and exhibited enlarged rough endoplasmic reticulum, mitochondria with well-preserved crests, conspicuous nucleoli and euchromatic chromatin. Other cells, such as mast cells, plasma cells and macrophages, were also observed.ConclusionHGF tissues had very similar ultrastructural characteristics to those of the NG. Oxytalan fibres were observed more frequently in HGF samples than NG samples. Other studies involving different HGF-harbouring families should be performed to better understand the pathogenesis of this hereditary condition.



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