Interferons and inflammasomes: co-operation and counter-regulation in disease

Publication date: Available online 24 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Larisa I. Labzin, Mario A.R. Lauterbach, Eicke Latz
Interferons (IFN) and the IL-1 family of cytokines have important roles in host defense against invading viruses and bacteria. Inflammasomes, multimeric cytosolic sensors of infection, are required for IL-1β and IL-18 processing and release. IFN, IL-1β and IL-18 are also implicated in autoimmune disease and chronic inflammation. While independent but complimentary pathways induce these cytokine subsets during infection, in some circumstances the cross-talk between these key inflammatory mediators is a particular requirement for effective host defense. In this review we will summarize recent discoveries concerning the potentiation of inflammasome responses by type 1 IFNs, particularly in Gram-negative bacterial infections, and reflect on the molecular mechanisms of IFNβ's immunosuppressive effects through modulation of inflammasome and IL-1β signaling in tuberculosis and multiple sclerosis.



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