Store-Operated Ca Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

Germinal center reactions are tightly regulated by follicular helper (Tfh) and regulatory (Tfr) T cells. Feske and colleagues demonstrate that both Tfh and Tfr cells critically depend on store-operated calcium entry (SOCE) to prevent autoimmunity and promote anti-viral immune responses.

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