Conformational IgE epitopes of peanut allergens Ara h 2 and Ara h 6

Abstract

Peanut allergy is the most prevalent food allergy in western countries. It affects 1-2% of the population and is the leading cause of fatal food-induced anaphylaxis [1, 2]. Despite recent progress in desensitization based on early administration of peanuts, oral immunotherapy, and epicutaneous administration, a generally useful, clinically approved treatment is not available [3-6]. Currently, the only treatment is strict avoidance of peanut, but this is difficult to achieve because of widespread use of peanut in prepared foods. [7, 8].

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