Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock

Host defense against gram-negative bacteria is facilitated by LPS recognition by TLR4-expressing immune cells, primarily macrophages. Coligan and colleagues identify CD300b as an LPS binding receptor and show that during acute infection (septic shock), CD300b-TLR4 complex formation regulates both TLR4-MyD88- and TLR4-TRIF-meditated signaling responses in macrophages, thereby augmenting lethal inflammation.

from #ENT via xlomafota13 on Inoreader http://ift.tt/1TUrumr
via IFTTT