Distinct mutations at the same positions of STAT3 cause either Loss or Gain of Function

Publication date: Available online 24 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Prabha Chandrasekaran, Ofer Zimmerman, Michelle Paulson, Elizabeth P. Sampaio, Alexandra F. Freeman, Kathryn J. Sowerwine, Darell Hurt, Julio C. Alcántara-Montiel, Amy P. Hsu, Steven M. Holland

Teaser

Distinct mutations at the same amino acids of STAT3 cause distinct clinical manifestations: the hyper IgE (Job's) syndrome or the syndrome of lymphoproliferation and autoimmunity.


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