FOXP3+ CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early life gut colonization

Publication date: Available online 30 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Sophia Björkander, Maria A. Johansson, Lena Hell, Gintare Lasaviciute, Caroline Nilsson, Ulrika Holmlund, Eva Sverremark-Ekström

Teaser

Peripheral CD4⁺FOXP3⁺ T-cells from children are immature and less responsive to S. aureus. Early gut colonization with S. aureus and lactobacilli associates with the functional phenotype of FOXP3⁺ cells, implying involvement of microbes in immune-maturation.


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