Abstract Purpose Literature on the relationship between hair cortisol concentration (HCC) and body mass index (BMI) is scarce and inconsistent in both preschoolers and parents. Thus, the study aimed to examine the relationships among HCC, perceived distress, coping, and BMI among low-income Head Start preschoolers and mothers. Methods A cross-sectional,...
Mon Sep 28, 2020 03:00
Radiotherapy is widely used to treat malignant tumors. It is mostly delivered in fractionated schemes, consisting of a daily small dose repeated during several weeks until a potentially curative dose has accumulated inside the tumor volume [1]. However, it is important to consider that shaped ionizing radiation beams intersect at the tumor site from successive angles, resulting in significant exposure of nearby healthy tissues to a wide range of daily subtherapeutic doses of ionizing radiation (SDIR).
Mon Sep 28, 2020 03:00
Abstract At this moment the world is fighting with COVID-19 pandemic. Because of increasing number of critical cases, the ICU admissions are also increasing and overwhelming the hospital. These group of patients often required Tracheostomy for proper management and ventilation. As Surgeons we often required to examine and perform procedures in head and neck patients and are in high risk of exposure to aerosol and droplet contamination. We did a literature search for research regarding...
Mon Sep 28, 2020 03:00
Abstract This study aims to describe the current epidemiological and etiological trends for deep neck space infections (DNIs) with an objective to understand the intricacies of their management. In this retrospective analytical study records of 52 patients with DNIs were reviewed. Patients having superficial abscess, peritonsillar abscess and abscess due to trauma/surgical procedure were excluded. Various epidemiological and etiological parameters (Demography, site, presentation,...
Mon Sep 28, 2020 03:00
Abstract The present study aimed at evaluating the prevalence of general and sinonasal symptoms in patients with olfactory symptoms and mild coronavirus disease-2019 (COVID-19) and determining the patterns in emergence and resolution of olfactory/gustatory symptoms relative to general and sinonassal symptoms. This was a prospective cross-sectional study conducted at the outpatient otorhinolaryngology clinic at a COVID-19-designated referral Hospital. We included consecutive patients...
Mon Sep 28, 2020 03:00
Abstract Objective to implement Universal Neonatal Hearing Screening (UNHS) in a tertiary academic hospital and identify associated risk factors. Prospective study. Screening tests with Otoacoustic Emissions (OAE) were done among newborns, prior to hospital discharge. In babies who fail OAE twice, Brain Response Audiometry (BERA) was done, failing which they were referred to higher ENT center for repeat testing and hearing rehabilitation. A total 2323 babies were admitted in the...
Mon Sep 28, 2020 03:00
Abstract The objective of the study was to study the outcomes of interlay type 1 tympanoplasty in large central perforations in terms of graft uptake, hearing improvement and complications. Study included 150 symptomatic patients having large central perforation in tympanic membrane willing for surgery who later underwent tympanoplasty with or without cortical mastoidectomy. All the patients selected for study, were assessed for subjective and objective evaluation pre-operatively...
Mon Sep 28, 2020 03:00
SARS-CoV-2 is a unique event, having emerged suddenly as a highly infectious viral pathogen for human populations. Previous phylogenetic analyses show its closest known evolutionary relative to be a virus detected in bats (RaTG13), with a common assumption that SARS-CoV-2 evolved from a zoonotic ancestor via recent genetic changes (likely in the Spike protein receptor binding domain, or RBD) that enabled it to infect humans. We used detailed phylogenetic analysis, ancestral sequence reconstruction,...
Mon Sep 28, 2020 03:00
Introduction. Knowledge and practice toward reproductive health right (RHR) is critical to protect young women, especially school girls, from unwanted reproductive outcomes as improving access to reproductive health services. However, the majority of young people including female secondary school students in Ethiopia have very little knowledge on the youth’s reproductive health rights. The aim of this study was to assess knowledge and practice toward reproductive health right among preparatory female...
Mon Sep 28, 2020 19:35
Abstract Introduction Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor of intermediate malignancy with tendency for local invasion and recurrence. The tumor almost exclusively occurs in children, especially in infants. Intracranial KHE are extremely rare with only two cases reported in the literature. Report We report the clinical and...
Mon Sep 28, 2020 03:00
Abstract Purpose The fusion of the upper cervical spine in children is demanding due to its reduced size, its anatomical complexity, or a severe pathology of the cranio-cervical junction. In some pediatric patients with today’s more popular C1–C2 or, occipito-C2 techniques, it is impossible, or very risky to perform a short upper cervical fixation. Methods ...
Mon Sep 28, 2020 03:00
Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with pandemics, but are still widely overlooked. We identify and characterize ORF3d, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not other closely related pangolin-CoVs or bat-CoVs. We then document evidence of ORF3d translation, characterize its protein sequence, and conduct an evolutionary...
Mon Sep 28, 2020 03:00
Previously, we showed that serum soluble interleukin-2 receptor (sIL-2R) levels, a marker for T-cell activation, were higher in complex regional pain syndrome (CRPS) patients than in healthy controls, suggesting pathogenic T-cell activation in CRPS. Additionally, sIL-2R levels discriminated well between CRPS and healthy controls with a high sensitivity (90%) and specificity (89.5%), suggesting a possible role for sIL-2R in the diagnosis of CRPS. In order to further validate this marker in the diagnostic...
Mon Sep 28, 2020 13:50
Abstract Introduction Currently, diagnosis of acute appendicitis (AA) is challenging. Here, we aim to propose using the new palpation sign to diagnose AA and establish the effectiveness of clinical examination using a proprietary diagnostic palpation procedure. Materials and methods We retrospectively analyzed 2,883 patients of all ages who were examined for suspected AA, of whom 532 patients required surgical intervention, using the new palpation sign. Patients were divided into three...
Mon Sep 28, 2020 18:50
Abstract Introduction We determine the location of the common facial vein (CFV) in a sample of neonates and assess the safety of this vein as an alternative access route for a central venous catheter (CVC). Materials and Methods We dissected both the left and right sides of the neck region of 24 neonatal, formalin‐fixed cadavers, exposing the underlying soft tissues and neurovascular structures. We identified the CFV, which we then pinned together with the internal jugular vein, cervical...
Mon Sep 28, 2020 19:29
Abstract Purpose The word “fixel” refers to the specific fiber population within each voxel, and fixel-based analysis (FBA) is a recently developed technique that facilitates fiber tract-specific statistical analysis. The aim of the paper is to apply FBA to detect impaired fibers for corticobasal syndrome (CBS) especially in regions that contain multiple crossed fibers. ...
02:46
Sprache · Stimme · GehörDOI: 10.1055/a-1127-5908 Hintergrund Kenntnisse über den typischen Ausspracheerwerb sind notwendig, um Aussprachestörungen identifizieren zu können. Hierbei spielt die phonologische Prozessanalyse eine wichtige Rolle. Informationen zum Ausspracheerwerb bilingualer Kinder sind bislang rar, sodass eine Diagnosestellung erschwert ist. Methode Mit Hilfe eines Bilderbenenntests wurden die phonologischen Prozesse im Deutschen von 84 türkisch-deutsch bilingualen...
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 733-740DOI: 10.1055/a-1021-2297Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 741-742DOI: 10.1055/a-1123-4558Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 680-681DOI: 10.1055/a-1123-4514Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 731-732DOI: 10.1055/a-1233-2321Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 674-675DOI: 10.1055/a-1240-1354Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 682-693DOI: 10.1055/a-1220-7045Die hereditäre hämorrhagische Teleangiektasie (HHT; Morbus Osler-Weber-Rendu; Morbus Osler) ist mit einer weltweiten Prävalenz von 1:5000–8000 eine seltene Erkrankung der Kapillaren, bei der sich arteriovenöse Shunts bilden. Vorwiegend finden sich diese in der Nasenschleimhaut, im Magen-Darm-Trakt, in der Lunge, in der Leber und im zentralen Nervensystem. Leitsymptom der Erkrankung ist die Epistaxis. Die Therapie besteht aus einem mehrstufigen...
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 672-674DOI: 10.1055/a-1116-3464Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 668-668DOI: 10.1055/a-1123-4393Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 671-672DOI: 10.1055/a-1250-5670Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 743-746DOI: 10.1055/a-1123-4569Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Laryngorhinootologie 2020; 99: 724-730DOI: 10.1055/a-1249-3458Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 28, 2020 02:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08254
Mon Sep 28, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09040
Mon Sep 28, 2020 07:00
An amendment to this paper has been published and can be accessed via the original article.
Mon Sep 28, 2020 03:00
Background Little is known about medical cannabis (MC)–related care for patients with cancer using MC. Methods Semistructured telephone interviews were conducted in a convenience sample of individuals (n = 24) with physician‐confirmed oncologic diagnoses and state/district authorization to use MC (Arizona, California, Florida, Illinois, Massachusetts, Oregon, New York, and Washington, DC) from April 2017 to March 2019. Standard qualitative techniques were used to assess the degree of MC‐related...
Mon Sep 28, 2020 22:00
Purpose: CDK12 aberrations have been reported as a biomarker of response to immunotherapy for metastatic castration-resistant prostate cancer (mCRPC). Herein, we characterize CDK12-mutated mCRPC, presenting clinical, genomic, and tumor-infiltrating lymphocyte data. Experimental Design: Patients with mCRPC consented to the molecular analyses of diagnostic and metastatic CRPC biopsies. Genomic analyses involved targeted next generation (MiSeqTM; Illumina) and exome sequencing (NovaSeqTM; Illumina)....
Mon Sep 28, 2020 16:08
Purpose: Mathematical models combined with new imaging technologies could improve clinical oncology studies. To improve detection of therapeutic effect in cancer patients, we assessed volumetric measurement of target lesions to estimate the rates of exponential tumor growth and regression as treatment is administered. Experimental Design: Two completed phase 3 trials were studied (988 patients) of aflibercept or panitumumab added to standard chemotherapy for advanced colorectal cancer. Retrospectively,...
Mon Sep 28, 2020 16:08
Purpose: Investigation of biological mechanisms underlying genetic alterations in cancer can assist the understanding of etiology and identify the potential prognostic biomarkers. Experimental design: We performed an integrative genomic analysis for a total of 731 NPC cases from five independent NPC cohorts to identify the genetic events associated with clinical outcomes. Results: In addition to the known mutational signatures associated with aging, APOBEC and mismatch repair (MMR), a new signature...
Mon Sep 28, 2020 16:08
Genome-wide DNA methylation profiles of serous tubal intraepithelial lesions (STICs) resemble methylation profiles of HGSOCs more closely than normal fallopian tube epithelium. While STICs and HGSOCs share subsets of common hypermethylated regions, DNA methylation can distinguish STICs from HGSOCs to provide proof-of-principle that DNA methylation can identify HGSOC initiation.
Mon Sep 28, 2020 16:08
Purpose: Relapsed acute myeloid leukemia (AML) post allogeneic-hematopoietic-cell-transplantation (allo-HCT) has a dismal prognosis. Experimental design: To assess prognosis of patients with recurrent-AML post allo-HCT over time, we analyzed EBMT-registry data of 8162 adult AML patients who relapsed between 2000 and 2018 after allo-HCT performed in first complete-remission from matched-sibling, unrelated or haploidentical-donors. Results: The 2-year overall-survival (OS) from relapse was 17%. For...
Mon Sep 28, 2020 16:08
Purpose: Determine if the androgen receptor (AR) inhibitor enzalutamide improves effectiveness of endrocrine therapy (ET) in hormone receptor-positive (HR+) breast cancer. Methods: In this phase 2 trial, patients with HR+/HER2-normal advanced/metastatic breast cancer were randomized 1:1 to exemestane 25 mg with placebo or exemestane 50 mg with enzalutamide 160 mg daily (NCT02007512). Two parallel cohorts enrolled patients with 0 (cohor 1) or 1 (cohort 2) prior ET for advanced disease. Progression-free...
Mon Sep 28, 2020 16:08
Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2 selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also emerged as important target and as a mechanism of resistance. Therefore, we developed a dual Bcl-2/Bcl-xL inhibitor that broadens the therapeutic activity while minimizing Bcl-xL-mediated thrombocytopenia. Experimental Design: We used structure-based chemistry...
Mon Sep 28, 2020 16:08
Abstract Purpose Verifying whether the mutation in COMT rs4818 could be involved in pain modulation. Methods Thirty-two individuals born with cleft lip and palate that underwent bone graft from the iliac crest bone were assessed at 12, 24, 48, 72 h, and 7 days regarding their pain experience using a visual analogic scale. DNA from each participant...
03:00
Abstract Purpose To study the relationship between OSA and risk of COVID-19 infection and disease severity, identified by the need for hospitalization and progression to respiratory failure. Methods We queried the electronic medical record system for an integrated health system of 10 hospitals in the Chicago metropolitan area to identify cases of COVID-19....
03:00
Abstract Acquisition of resistance to gemcitabine is a challenging clinical and biological hallmark property of refractory pancreatic cancer. Here, we investigated whether glycogen synthase kinase (GSK)‐3β, an emerging therapeutic target in various cancer types, is mechanistically involved in acquired resistance to gemcitabine in human pancreatic cancer. This study included 3 gemcitabine‐sensitive BxPC‐3 cell‐derived clones (BxG30, BxG140, BxG400) that acquired stepwise resistance to gemcitabine...
Mon Sep 28, 2020 18:53
Abstract Rare cancers are a group of approximately 200 malignancies with extremely low incidences and with a wide variety of genotypes and phenotypes. Collectively, they are more common than any single malignancy. However, given the small numbers of individuals diagnosed with rare cancers, it is difficult to design clinical trials with sufficient patient numbers. Therefore, few effective anticancer drugs have been developed, and evidence‐based medicine is not always feasible for rare cancers. Consequently,...
Mon Sep 28, 2020 18:56
Small regulatory RNAs (sRNAs) play an important role for posttranscriptional gene regulation in bacteria. sRNAs recognize their target messenger RNAs (mRNAs) by base pairing, which is often facilitated by interactions with the bacterial RNA-binding proteins Hfq or ProQ. The FinO/ProQ RNA-binding protein domain was first discovered in the bacterial repressor of conjugation, FinO. Since then, the functional role of FinO/ProQ-like proteins in posttranscriptional gene regulation was extensively studied...
Mon Sep 28, 2020 17:56
Coronavirus EndoU inhibits dsRNA-activated antiviral responses; however, the physiologic RNA substrates of EndoU are unknown. In this study, we used mouse hepatitis virus (MHV)-infected bone-marrow-derived macrophage (BMM) and cyclic phosphate cDNA sequencing to identify the RNA targets of EndoU. EndoU targeted viral RNA, cleaving the 3' side of pyrimidines with a strong preference for UA and CA sequences (endoYA). EndoU-dependent cleavage was detected in every region of MHV RNA, from the 5' NTR...
Mon Sep 28, 2020 20:10
It is only after recent advances in cryo-electron microscopy that it is now possible to describe at high-resolution structures of large macromolecules that do not crystalize. Purified 30S subunits interconvert between an "active" and "inactive" conformations. The active conformation was described by crystallography in the early 2000s, but the structure of the inactive form at high resolution remains unsolved. Here we used cryo-electron microscopy to obtain the structure of the inactive conformation...
Mon Sep 28, 2020 21:17
Oncogenesis, Published online: 28 September 2020; doi:10.1038/s41389-020-00271-1Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation
Mon Sep 28, 2020 03:00
Hybrids between species often show extreme phenotypes, including some that take place at the molecular level. In this study, we investigated the phenotypes of an interspecies diploid hybrid in terms of protein-protein interactions inferred from protein correlation profiling. We used two yeast species, Saccharomyces cerevisiae and Saccharomyces uvarum, which are interfertile, but yet have proteins diverged enough to be differentiated using mass spectrometry. Most of the protein-protein interactions...
Mon Sep 28, 2020 03:00
Hidden Markov models (HMM) have emerged as an important tool for understanding the evolution of characters that take on discrete states. Their flexibility and biological sensibility make them appealing for many phylogenetic comparative applications. Previously available packages placed unnecessary limits on the number of observed and hidden states that can be considered when estimating transition rates and inferring ancestral states on a phylogeny. To address these issues, we expanded the capabilities...
Mon Sep 28, 2020 03:00
With the dynamic advancement of digitalization, working environments are changing and risk for employee stress may be increasing. Work stress has been associated with a dysregulation of inflammatory processes ...
Mon Sep 28, 2020 03:00
Racism is increasingly recognised internationally as a key factor contributing to health disparities. A comprehensive body of strong research from international authors has reported negative associations betwe...
Mon Sep 28, 2020 03:00
Atopic dermatitis (AD) is an inflammatory chronic condition that affects the skin of children and adults and has an important impact on the quality of life. Treatments for AD are based on environmental control...
Mon Sep 28, 2020 03:00
Expenditure on driver-related behavioral interventions and road use policy is often justified by their impact on the frequency of fatal and serious injury crashes. Given the rarity of fatal and serious injury ...
Mon Sep 28, 2020 03:00
Abstract Background Gangliogliomas are neoplastic lesions composed by a mixed population of neoplastic glial and dysplastic neural cells. They represent around 5% of all CNS tumors in the pediatric population. These usually are well-differentiated, slow-growing tumors, meaning that complete resection could cure most of these patients. Although most lesions remain stable over time after incomplete resection, some patients develop progression...
Mon Sep 28, 2020 03:00
A new era of surgical visualization and magnification is poised to disrupt the field of otology and neurotology. The once revolutionary benefits of the binocular microscope are now shared with rigid endoscopes and exoscopes. These two modalities are complementary. The endoscope improves visualization of the hidden recesses through the external auditory canal or canal up mastoidectomy. The exoscope provides an immersive visual experience and superior ergonomics compared to binocular microscopy. Endoscopes...
Mon Sep 28, 2020 03:00
The shade avoidance response is a set of developmental changes exhibited by plants to avoid shading by competitors, and is an important model of adaptive plant plasticity. While the mechanisms of sensing shading by other plants are well-known and appear conserved across plants, less is known about the developmental mechanisms that result in the diverse array of morphological and phenological responses to shading. This is particularly true for traits that appear later in plant development. Here we...
Mon Sep 28, 2020 23:51
Both polyploidization and transposable element (TE) activity are known to be major drivers of plant genome evolution. Here, we utilize the Zea-Tripsacum clade to investigate TE activity and accumulation after a shared polyploidization event. Comparisons of TE evolutionary dynamics in various Zea and Tripsacum species, in addition to two closely related diploid species, Urelytrum digitatum and Sorghum bicolor, revealed variation in repeat content among all taxa included in the study. The repeat composition...
Mon Sep 28, 2020 23:51
Thyroid, Ahead of Print.
Fri Sep 25, 2020 10:00
Thyroid, Ahead of Print.
Fri Sep 25, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Thu Sep 24, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Sep 25, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Fri Sep 25, 2020 10:00
Soft Robotics, Ahead of Print.
Fri Sep 25, 2020 10:00
Abstract Object Increasing age is a known negative prognostic factor for glioblastoma. However, a multifactorial approach is necessary to achieve optimal neuro-oncological treatment. It remains unclear to what extent frailty, comorbidity burden, and obesity might exert influence on survival in geriatric glioblastoma patients. We have therefore reviewed our institutional database to assess the prognostic value of these factors in elderly...
03:00
Future Oncology, Ahead of Print.
Mon Sep 28, 2020 04:36
Future Oncology, Ahead of Print.
Mon Sep 28, 2020 11:52
Future Oncology, Ahead of Print.
Mon Sep 28, 2020 12:04
Surgical Infections, Ahead of Print.
Wed Sep 23, 2020 10:00
Abstract Introduction Supra-total resection in terms of anterior temporal lobectomy (ATL) has gained growing attention with regard to superior long-term disease control for temporal-located glioblastoma. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—may be associated with peri- and postoperative unfavorable events which significantly worsen initial favorable postoperative outcome....
03:00
Stem Cells and Development, Ahead of Print.
Thu Sep 24, 2020 10:00
Abstract Tularemia is a bacterial disease of humans, wild, and domestic animals. Francisella tularensis, which is a Gram-negative coccobacillus-shaped bacterium, is the causative agent of tularemia. Recently, an increase in the number of human tularemia cases has been noticed in several countries around the world. It has been reported mostly from North America, several Scandinavian countries, and certain Asian countries. The disease spreads through vectors such as mosquitoes,...
Mon Sep 28, 2020 03:00
Abstract Rationale Stress is associated with increased sensitivity to threat. Previous investigations examining how stress affects threat processing have largely focused on biomarker responses associated with either the sympathetic-nervous-system (SNS) or the hypothalamus-pituitary-adrenal (HPA) axis. Objectives We pharmacologically suppressed...
08:12
Abstract Background Ethanol use disorders are a serious medical and public health problem in the world today. Acute ethanol intoxication can lead to cognitive dysfunction such as learning and memory impairment. Gamma oscillations (γ, 30–80 Hz) are synchronized rhythmic activity generated by population of neurons within local network, and closely related to learning and memory function. The hippocampus is a critical anatomic structure...
08:12
Abstract Rationale Previous studies suggested that methionine (Met) levels are decreased in depressed patients. However, whether the decrease in this amino acid is important for phenotypic behaviors associated with depression has not been deciphered. Objective The response of individuals to chronic stress is variable, with some individuals developing...
08:12
Abstract Rationale Working memory depends on prefrontal cortex functioning, which is particularly sensitive to levels of noradrenaline. Studies in non-human primates have shown that modest levels of noradrenaline improve working memory, and that higher levels of noradrenaline impair working memory performance. However, research in humans provided inconsistent findings concerning noradrenergic effects on working memory. ...
08:12
Abstract Rational Minocycline is a second-generation, semi-synthetic tetracycline, and has broad spectrum-antibacterial activity. Interestingly, many studies have demonstrated that minocycline is beneficial for depression, which may be due to its effects on neuroinflammation modulation. Recently, gut microbiota imbalance has been found in depression patient and animal models. ...
08:12
The title of this article is “mRNA and microRNA profiles are associated with stress susceptibility and resilience induced by psychological stress in the prefrontal cortex.
08:12
Abstract Early life stress influences adult psychopathology and is associated with an increase in the propensity for drug use/seeking throughout the lifespan. Animal models corroborate that stress exposure exacerbates maladaptive reactivity to stressful stimuli while also shifting the rewarding properties of many drugs of abuse, including nicotine (NIC), a stimulant commonly misused by adolescents. Interestingly, NIC treatment can also normalize some stress-induced behavioral...
08:12
Abstract Rationale Peroxisome Proliferator Activator receptors (PPARs) are intracellular receptors that function as transcription factors, which regulate specific metabolic and inflammatory processes. PPARs are broadly distributed in the body and are also expressed in the central nervous system, especially in areas involved in addiction-related behavioral responses. Recent studies support a role of PPARs in alcoholism and pioglitazone:...
08:12
Abstract Rationale Anxiety is one of the most comorbid conditions with major depressive disorder (MDD). Depression-associated anxiety often stems from the dysfunctional hypothalamic-pituitary-adrenal (HPA) axis and its altered regulation by the amygdala. Furthermore, MDD is associated with altered glutamatergic processing leading to anxiety and impaired regulation of the HPA axis. Recent studies have demonstrated that N-acetyl cysteine...
08:12
Abstract Rationale Stress plays a major role in the development of alcohol use disorder (AUD)—a history of chronic stress contributes to alcohol misuse, and withdrawal from alcohol elevates stress, perpetuating cycles of problematic drinking. Recent studies have shown that, in male mice, repeated chronic intermittent ethanol (CIE) and stress elevates alcohol use above either manipulation alone and impacts cognitive functions such...
08:12
Abstract Rationale There are controversial reports on the effects of gabapentin in respect to psychotic symptoms. Prepulse inhibition of the acoustic startle response is an operational measure of sensorimotor gating. In laboratory rodents, deficits in sensorimotor gating are used to model behavioral endophenotypes of schizophrenia. Sleep deprivation disrupts prepulse inhibition and can be used as a psychosis model to evaluate effects...
08:12
Abstract Objectives The prefrontal cortex is associated with many mental neurological diseases. The mRNA and microRNA profiles of stress susceptibility and resilience induced by psychological stress in the prefrontal cortex remain to be elucidated. Methods The C57 observer was placed in the cage next to the CD1 mouse and suffered psychological...
08:12
Abstract Purpose The COVID-19 outbreak witnessed in the first months of 2020 has led to unprecedented changes in society’s lifestyles. In the current study, we aimed to investigate the effect of this unexpected context on sleep. Methods During the COVID-19 outbreak, we performed an online survey with individuals formerly recruited for validation of...
03:00
Polygenic adaptation is thought to be an important mechanism of phenotypic evolution in humans, although recent evidence of confounding due to residual stratification in consortium GWAS made studies of polygenic adaptation more difficult to interpret. Using FST as a measure of allele frequency differentiation, a previous study has shown that the mean FST among African, East Asian, and European populations is significantly higher at height-associated SNPs than that found at matched non-associated...
Mon Sep 28, 2020 03:00
Introduction: Recent guidelines of the American Thyroid Association (ATA) suggest that a lobectomy may be sufficient to treat low- to intermediate-risk patients with thyroid tumors ≤40 mm, without extrathyroidal extension or lymph node metastases. The present study aimed to evaluate long-term recurrence after lobectomy for differentiated thyroid cancer and to analyze factors associated with recurrence. Methods: In this retrospective cohort study, patients who underwent a lobectomy for thyroid cancer...
09:22
This is an MRI image obtain in alcoholic beggar presented with ataxia, ophthalmoplegia and acute confusional state. Red arrow shows hyperintense signal around mamillary bodies and yellow arrow around periaqueductal area.Important Point :MRI in wernicke's encephalopathy shows hyperintense T2/FLAIR signal involving the mamillary bodies, dorsomedial thalami, tectal plate, periaqueductal area, and around 3rd ventricle.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com...
09:05
Abstract The experiment was performed in support of a Japanese initiative to investigate the biological effects of irradiation from residual neutron-activated radioactivity that resulted from the A-bombing. Radionuclide 56Mn (T1/2 = 2.58 h) is one of the main neutron-activated emitters during the first hours after neutron activation of soil dust particles. In our previous studies (2016–2017) related to irradiation of male Wistar rats after dispersion of 56MnO2 powder, the internal...
03:00
Journal of Cutaneous Medicine and Surgery, Ahead of Print. ImportanceSystemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression.ObjectiveIn this manuscript we provide a summary of all investigated potential external risk factors for SSc.Data sourcesA literature search...
08:51
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
08:53
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