Antibiotics, Vol. 9, Pages 651: Acquisition Risk Factors of the SCCmec IX-Methicillin-Resistant Staphylococcus aureus in Swine Production Personnel in Chiang Mai and Lamphun Provinces, Thailand Antibiotics doi: 10.3390/antibiotics9100651 Authors: Peerapat Rongsanam Terdsak Yano Wuttipong Yokart Panuwat Yamsakul Suweera Sutammeng Ratchadaporn Udpaun Duangporn Pichpol Decha Tamdee Usanee Anukool Methicillin-resistant Staphylococcus aureus (MRSA) harboring the type-IX...
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Antibiotics, Vol. 9, Pages 650: Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections Antibiotics doi: 10.3390/antibiotics9100650 Authors: Evan Delancey Devin Allison Hansa Raj KC David F. Gilmore Todd Fite Alexei G. Basnakian Mohammad A. Alam Acinetobacter baumannii has emerged as one of the most lethal drug-resistant bacteria in recent years. We report...
Mon Sep 28, 2020 03:00
Antibiotics, Vol. 9, Pages 649: Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria Antibiotics doi: 10.3390/antibiotics9100649 Authors: Annamária Kincses Stefánia Szabó Bálint Rácz Nikoletta Szemerédi Genki Watanabe Ryosuke Saijo Hiroshi Sekiya Eiji Tamai Joseph Molnár Masami Kawase Gabriella Spengler Bacteria often show resistance against antibiotics due to various mechanisms such as the expression of efflux pumps, biofilm formation,...
Mon Sep 28, 2020 03:00
Antibiotics, Vol. 9, Pages 648: A Review on Revolutionary Natural Biopolymer-Based Aerogels for Antibacterial Delivery Antibiotics doi: 10.3390/antibiotics9100648 Authors: Esam Bashir Yahya Fauziah Jummaat A. A. Amirul A. S. Adnan N. G. Olaiya C. K. Abdullah Samsul Rizal M. K. Mohamad Haafiz H. P. S. Abdul Khalil A biopolymer-based aerogel has been developed to become one of the most potentially utilized materials in different biomedical applications. The biopolymer-based...
Mon Sep 28, 2020 03:00
Antioxidants, Vol. 9, Pages 929: Microvesicle Formation Induced by Oxidative Stress in Human Erythrocytes Antioxidants doi: 10.3390/antiox9100929 Authors: Julia Sudnitsyna Elisaveta Skverchinskaya Irina Dobrylko Elena Nikitina Stepan Gambaryan Igor Mindukshev Extracellular vesicles (EVs) released by different cell types play an important role in many physiological and pathophysiological processes. In physiological conditions, red blood cell (RBC)-derived EVs compose 4–8%...
Mon Sep 28, 2020 03:00
Antioxidants, Vol. 9, Pages 930: Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia Antioxidants doi: 10.3390/antiox9100930 Authors: Enrico Gugliandolo Marika Cordaro Rosalba Siracusa Ramona D’Amico Alessio Filippo Peritore Tiziana Genovese Daniela Impellizzeri Rosanna Di Paola Rosalia Crupi Salvatore Cuzzocrea Roberta Fusco Background: Intestinal...
Mon Sep 28, 2020 03:00
Antioxidants, Vol. 9, Pages 928: Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease Antioxidants doi: 10.3390/antiox9100928 Authors: Jung Hwa Seo Seong-Woong Kang Kyungri Kim Soohyun Wi Jang Woo Lee Sung-Rae Cho Although environmental enrichment (EE) is known to reduce oxidative stress in Parkinson’s disease (PD), the metabolic alternations for detoxifying endogenous...
Mon Sep 28, 2020 03:00
Antioxidants, Vol. 9, Pages 927: Characterization of the Age-Dependent Changes in Antioxidant Defenses and Protein’s Sulfhydryl/Carbonyl Stress in Human Follicular Fluid Antioxidants doi: 10.3390/antiox9100927 Authors: Alice Luddi Laura Governini Angela Capaldo Giovanna Campanella Vincenzo De Leo Paola Piomboni Giuseppe Morgante The oxidative stress, characterized by the imbalance between pro-oxidants and antioxidants molecules, seems to be involved in the pathogenesis...
Mon Sep 28, 2020 03:00
Arts, Vol. 9, Pages 100: Mythical Islands of Value: Free Ports, Offshore Capitalism, and Art Capital
Arts, Vol. 9, Pages 100: Mythical Islands of Value: Free Ports, Offshore Capitalism, and Art Capital Arts doi: 10.3390/arts9040100 Authors: Erik Post Filipe Calvão The Geneva Free Port in Switzerland has paved the way for a new generation of art and luxury free ports. These are critical spatial pivots for the management of art assets, including storage and transactions of artworks, and serve as proxy to examine mechanisms for the capture and generation of value, integral but also...
Mon Sep 28, 2020 03:00
Biomedicines, Vol. 8, Pages 386: Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing Biomedicines doi: 10.3390/biomedicines8100386 Authors: Anika Haq Suneel Kumar Yong Mao Francois Berthiaume Bozena Michniak-Kohn The purpose of this study was to synthesize and characterize novel biocompatible topical polymeric film and hydrogel systems that have the potential to deliver the antibacterial agent thymoquinone (TQ) directly to the skin...
Mon Sep 28, 2020 03:00
Biomedicines, Vol. 8, Pages 387: Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs) Biomedicines doi: 10.3390/biomedicines8100387 Authors: Yan Yan Clare Chang Junyi Su Morten T. Venø Jørgen Kjems Multipotent stem cells (MSCs) are used in various therapeutic applications based on their paracrine secretion activity. Here, we set out to identify and characterize the paracrine factors released during osteoblastogenesis,...
Mon Sep 28, 2020 03:00
Biomedicines, Vol. 8, Pages 385: Evi1 Counteracts Anti-Leukemic and Stem Cell Inhibitory Effects of All-Trans Retinoic Acid on Flt3-ITD/Npm1c-Driven Acute Myeloid Leukemia Cells Biomedicines doi: 10.3390/biomedicines8100385 Authors: Chi Huu Nguyen Alexander M. Grandits George S. Vassiliou Philipp B. Staber Gerwin Heller Rotraud Wieser All-trans retinoic acid (atRA) has a dramatic impact on the survival of patients with acute promyelocytic leukemia, but its therapeutic...
Mon Sep 28, 2020 03:00
Biomedicines, Vol. 8, Pages 384: Idebenone Protects against Spontaneous Chronic Murine Colitis by Alleviating Endoplasmic Reticulum Stress and Inflammatory Response Biomedicines doi: 10.3390/biomedicines8100384 Authors: Sonia Shastri Tanvi Shinde Agampodi Promoda Perera Nuri Gueven Rajaraman Eri Endoplasmic reticulum (ER) stress in intestinal secretory goblet cells has been linked to the development of ulcerative colitis (UC). Emerging evidence suggests that the short chain...
Mon Sep 28, 2020 03:00
Biomedicines, Vol. 8, Pages 383: Evaluation of Root-End Preparation with Two Different Endodontic Microsurgery Ultrasonic Tips Biomedicines doi: 10.3390/biomedicines8100383 Authors: Paulo J. Palma Joana A. Marques Margarida Casau André Santos Francisco Caramelo Rui I. Falacho João Miguel Santos The aim of this study is to compare root-end preparation performed with two different ultrasonic tips—CVDentus and NSK—and respective time requirements. After...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1385: Assigning the Origin of Microbial Natural Products by Chemical Space Map and Machine Learning Biomolecules doi: 10.3390/biom10101385 Authors: Alice Capecchi Jean-Louis Reymond Microbial natural products (NPs) are an important source of drugs, however, their structural diversity remains poorly understood. Here we used our recently reported MinHashed Atom Pair fingerprint with diameter of four bonds (MAP4), a fingerprint suitable for molecules across...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1384: Membrane Interaction of Ibuprofen with Cholesterol-Containing Lipid Membranes Biomolecules doi: 10.3390/biom10101384 Authors: Jan Kremkow Meike Luck Daniel Huster Peter Müller Holger A. Scheidt Deciphering the membrane interaction of drug molecules is important for improving drug delivery, cellular uptake, and the understanding of side effects of a given drug molecule. For the anti-inflammatory drug ibuprofen, several studies reported contradictory...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1383: Toolbox Accelerating Glycomics (TAG): Glycan Annotation from MALDI-TOF MS Spectra and Mapping Expression Variation to Biosynthetic Pathways Biomolecules doi: 10.3390/biom10101383 Authors: Miura Hanamatsu Yokota Okada Furukawa Shinohara Glycans present extraordinary structural diversity commensurate with their involvement in numerous fundamental cellular processes including growth, differentiation, and morphogenesis. Unlike linear...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1382: Comparative Characterization of Two cxcl8 Homologs in Oplegnathus fasciatus: Genomic, Transcriptional and Functional Analyses Biomolecules doi: 10.3390/biom10101382 Authors: Navaneethaiyer Umasuthan SDNK Bathige William Shanthakumar Thulasitha Minyoung Oh Jehee Lee CXCL8 (interleukin-8, IL-8) is a CXC family chemokine that recruits specific target cells and mediates inflammation and wound healing. This study reports the identification and...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1379: Computational and In Vitro Investigation of (-)-Epicatechin and Proanthocyanidin B2 as Inhibitors of Human Matrix Metalloproteinase 1 Biomolecules doi: 10.3390/biom10101379 Authors: Kyung Eun Lee Shiv Bharadwaj Umesh Yadava Sang Gu Kang Matrix metalloproteinases 1 (MMP-1) energetically triggers the enzymatic proteolysis of extracellular matrix collagenase (ECM), resulting in progressive skin aging. Natural flavonoids are well known for their...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1380: Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress Biomolecules doi: 10.3390/biom10101380 Authors: Anil Kumar Yadav Byeong-Churl Jang Notably, 6-Shogaol, a bioactive natural substance, has anticancer effects on many types of tumors. Up to date, the anticancer effect and mode of action of 6-Shogaol on liposarcoma are not known. In this study,...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1378: Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology Biomolecules doi: 10.3390/biom10101378 Authors: Saiful E. Syafruddin M. Aiman Mohtar Wan Fahmi Wan Mohamad Nazarie Teck Yew Low The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1377: Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma Biomolecules doi: 10.3390/biom10101377 Authors: Yu-Chan Chang Ming-Huang Chen Chun-Nan Yeh Michael Hsiao Cholangiocarcinoma (CCA) has been identified as a highly malignant cancer that can be transformed from epithelial cells of the bile duct, including intrahepatic, perihilar and extrahepatic. High-resolution imaging tools (abdominal ultrasound, computed tomography...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1375: A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells Biomolecules doi: 10.3390/biom10101375 Authors: Fatin Jannus Marta Medina-O’Donnell Francisco Rivas Luis Díaz-Ruiz Eva E. Rufino-Palomares José A. Lupiáñez Andrés Parra Fernando J. Reyes-Zurita Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Our...
Mon Sep 28, 2020 03:00
Biomolecules, Vol. 10, Pages 1376: Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance Biomolecules doi: 10.3390/biom10101376 Authors: Ewa Gibula-Tarlowska Jolanta H. Kotlinska Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations. Such studies indicate that some endogenous neuropeptides, called anti-opioids, participate...
Mon Sep 28, 2020 03:00
Biosensors, Vol. 10, Pages 137: Lyme Disease Biosensors: A Potential Solution to a Diagnostic Dilemma Biosensors doi: 10.3390/bios10100137 Authors: Connor Flynn Anna Ignaszak Over the past four decades, Lyme disease has remained a virulent and pervasive illness, persisting throughout North America and many other regions of the world. Recent increases in illness in many countries has sparked a renewed interest in improved Lyme diagnostics. While current standards of diagnosis are acceptable...
Mon Sep 28, 2020 03:00
Brain Sciences, Vol. 10, Pages 686: Comparison of Modern Highly Interactive Flicker-Free Steady State Motion Visual Evoked Potentials for Practical Brain–Computer Interfaces Brain Sciences doi: 10.3390/brainsci10100686 Authors: Piotr Stawicki Ivan Volosyak Motion-based visual evoked potentials (mVEP) is a new emerging trend in the field of steady-state visual evoked potentials (SSVEP)-based brain–computer interfaces (BCI). In this paper, we introduce different movement-based...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2789: Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation Cancers doi: 10.3390/cancers12102789 Authors: Aleksandar Radujkovic Lambros Kordelas Rashit Bogdanov Carsten Müller-Tidow Dietrich W. Beelen Peter Dreger Thomas Luft Interleukin-18 (IL-18) is an immunoregulatory cytokine and a context-dependent regulator of hematopoietic stem/progenitor cell (HSPC) quiescence in murine models. In a previous study, high...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2786: Granzyme B Degraded Type IV Collagen Products in Serum Identify Melanoma Patients Responding to Immune Checkpoint Blockade Cancers doi: 10.3390/cancers12102786 Authors: Christina Jensen Dovile Sinkeviciute Daniel Hargbøl Madsen Patrik Önnerfjord Morten Hansen Henrik Schmidt Morten Asser Karsdal Inge Marie Svane Nicholas Willumsen A T-cell permissive tumor microenvironment, characterized by the presence of activated T cells and low...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2787: Characteristics and Clinical Outcome of Breast Cancer Patients with Asymptomatic Brain Metastases Cancers doi: 10.3390/cancers12102787 Authors: Elena Laakmann Isabell Witzel Tanja Neunhöffer Rudolf Weide Marcus Schmidt Tjoung-Won Park-Simon Volker Möbus Christoph Mundhenke Arkadius Polasik Kristina Lübbe Tobias Hesse Kerstin Riecke Marc Thill Peter A. Fasching Carsten Denkert Tanja Fehm Valentina Nekljudova Julia...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2783: Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies Cancers doi: 10.3390/cancers12102783 Authors: Qi-Yao Wei Yan-Ming Xu Andy T. Y. Lau Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2785: Angiotensin Inhibition, TGF-β and EMT in Cancer Cancers doi: 10.3390/cancers12102785 Authors: Fabian Bernhard Pallasch Udo Schumacher Angiotensin inhibitors are standard drugs in cardiovascular and renal diseases that have antihypertensive and antifibrotic properties. These drugs also exert their antifibrotic effects in cancer by reducing collagen and hyaluronan deposition in the tumor stroma, thus enhancing drug delivery. Angiotensin II signaling interferes...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2788: Dual-Time Point [68Ga]Ga-PSMA-11 PET/CT Hybrid Imaging for Staging and Restaging of Prostate Cancer Cancers doi: 10.3390/cancers12102788 Authors: Manuela A. Hoffmann Hans-Georg Buchholz Helmut J Wieler Florian Rosar Matthias Miederer Nicolas Fischer Mathias Schreckenberger Routine [68Ga]Ga-PSMA-11 PET/CT (one hour post-injection) has been shown to accurately detect prostate cancer (PCa) lesions. The goal of this study is to evaluate the...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2782: Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells Cancers doi: 10.3390/cancers12102782 Authors: Ruben Verloy Angela Privat-Maldonado Evelien Smits Annemie Bogaerts Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2781: Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? Cancers doi: 10.3390/cancers12102781 Authors: Francesco Longo Francesco Perri Francesco Caponigro Giuseppina Della Vittoria Scarpati Agostino Guida Ettore Pavone Corrado Aversa Paolo Muto Mario Giuliano Franco Ionna Raffaele Solla Head and neck squamous cell carcinomas (SCCHN)...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2784: Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis Cancers doi: 10.3390/cancers12102784 Authors: Jerry Xiao Joseph R. McGill Kelly Stanton Joshua D. Kassner Sujata Choudhury Richard Schlegel Zuben E. Sauna Paula R. Pohlmann Seema Agarwal Circulating tumor cells (CTCs) represent a unique population of cells that can be used to investigate the mechanistic underpinnings of metastasis. Unfortunately,...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2777: The Role of Surgery in Lung Cancer Treatment Cancers doi: 10.3390/cancers12102777 Authors: Francesco Petrella [...]
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2779: Geriatric Nutritional Risk Index Less Than 92 Is a Predictor for Late Postpancreatectomy Hemorrhage Following Pancreatoduodenectomy: A Retrospective Cohort Study Cancers doi: 10.3390/cancers12102779 Authors: Naotake Funamizu Kenji Omura Yasutsugu Takada Takahiro Ozaki Kohei Mishima Kazuharu Igarashi Go Wakabayashi Postpancreatectomy hemorrhage (PPH) is the most lethal complication of pancreatoduodenectomy (PD). The main risk factor for...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2780: The Metabolic Heterogeneity and Flexibility of Cancer Stem Cells Cancers doi: 10.3390/cancers12102780 Authors: Atsushi Tanabe Hiroeki Sahara Numerous findings have indicated that CSCs, which are present at a low frequency inside primary tumors, are the main cause of therapy resistance and cancer recurrence. Although various therapeutic methods targeting CSCs have been attempted for eliminating cancer cells completely, the complicated characteristics of...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2778: Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease: A Step Forward for Better Evaluation Using Ultrasound Elastography Cancers doi: 10.3390/cancers12102778 Authors: Monica Lupsor-Platon Teodora Serban Alexandra-Iulia Silion Alexandru Tirpe Mira Florea The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in the general population prompts for a quick response from physicians. As NAFLD can progress to liver fibrosis,...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2776: Prognostic Role of Serum Cytokeratin-19 Fragment (CYFRA 21-1) in Patients with Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12102776 Authors: Gian Paolo Caviglia Michela Ciruolo Antonella Olivero Patrizia Carucci Emanuela Rolle Chiara Rosso Maria Lorena Abate Alessandra Risso Davide Giuseppe Ribaldone Francesco Tandoi Giorgio Maria Saracco Elisabetta Bugianesi Silvia Gaia Keratin 19 (K19) is a cancer stem cell...
Mon Sep 28, 2020 03:00
Cancers, Vol. 12, Pages 2775: Frontiers of Robotic Gastroscopy: A Comprehensive Review of Robotic Gastroscopes and Technologies Cancers doi: 10.3390/cancers12102775 Authors: Wojciech Marlicz Xuyang Ren Alexander Robertson Karolina Skonieczna-Żydecka Igor Łoniewski Paolo Dario Shuxin Wang John N Plevris Anastasios Koulaouzidis Gastone Ciuti Upper gastrointestinal (UGI) tract pathology is common worldwide. With recent advancements in robotics, innovative diagnostic...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2192: Cells in Cardiovascular Disease: Using Diversity to Confront Adversity Cells doi: 10.3390/cells9102192 Authors: José Martínez-González Pablo García de Frutos The present Special Issue on “Cells in Cardiovascular Disease” wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory...
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Cells, Vol. 9, Pages 2191: Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery Cells doi: 10.3390/cells9102191 Authors: Xuan T. T. Dang Jayasinghe Migara Kavishka Daniel Xin Zhang Marco Pirisinu Minh T. N. Le Despite the recent advances in drug development, the majority of novel therapeutics have not been successfully translated into clinical applications. One of the major factors hindering their clinical translation is the lack of a safe, non-immunogenic...
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Cells, Vol. 9, Pages 2193: Stem Cell-Based Disease Modeling and Cell Therapy Cells doi: 10.3390/cells9102193 Authors: Xiaowen Bai Stem cell science is among the fastest moving fields in biology, with many highly promising directions for translatability. To centralize and contextualize some of the latest developments, this Special Issue presents state-of-the-art research of adult stem cells, induced pluripotent stem cells (iPSCs), and embryonic stem cells as well as cancer stem cells....
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Cells, Vol. 9, Pages 2190: JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases Cells doi: 10.3390/cells9102190 Authors: Musi Agrò Santarella Iervasi Borsello The c-Jun N-terminal kinase 3 (JNK3) is the JNK isoform mainly expressed in the brain. It is the most responsive to many stress stimuli in the central nervous system from ischemia to Aβ oligomers toxicity. JNK3 activity is spatial and temporal organized by...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2188: When the Search for Stemness Genes Meets the Skin Substitute Bioengineering Field: KLF4 Transcription Factor under the Light Cells doi: 10.3390/cells9102188 Authors: Fortunel Martin The transcription factor “Kruppel-like factor 4” (KLF4) is a central player in the field of pluripotent stem cell biology. In particular, it was put under the spotlight as one of the four factors of the cocktail originally described for reprogramming into...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2189: Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation Cells doi: 10.3390/cells9102189 Authors: Shah Alam Antonia Piazzesi Mariam Abd El Fatah Maren Raucamp Gerhild van Echten-Deckert We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage. Interestingly,...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2186: Role of Vitamin K-dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis Cells doi: 10.3390/cells9102186 Authors: Anna Tutusaus Montserrat Marí José T. Ortiz-Pérez Gerry A.F. Nicolaes Albert Morales Pablo García de Frutos The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2183: Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases Cells doi: 10.3390/cells9102183 Authors: Tuuli-Maria Sonninen Gundars Goldsteins Nihay Laham-Karam Jari Koistinaho Šárka Lehtonen Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins,...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2184: IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions Cells doi: 10.3390/cells9102184 Authors: Doreen M. Floss Jens M. Moll Jürgen Scheller Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2185: Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology Cells doi: 10.3390/cells9102185 Authors: Vanessa Dubois Bart Staels Philippe Lefebvre Michael P. Verzi Jérôme Eeckhoute Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2187: Aquaporin-4 Expression during Toxic and Autoimmune Demyelination Cells doi: 10.3390/cells9102187 Authors: Sven Olaf Rohr Theresa Greiner Sarah Joost Sandra Amor Paul van der Valk Christoph Schmitz Markus Kipp The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood–brain interface. Following the discovery that AQP4 is a possible autoantigen in neuromyelitis optica, the function...
Mon Sep 28, 2020 03:00
Cells, Vol. 9, Pages 2182: The Protective Effect of Exercise in Neurodegenerative Diseases: The Potential Role of Extracellular Vesicles Cells doi: 10.3390/cells9102182 Authors: Oliver K Fuller Martin Whitham Suresh Mathivanan Mark A Febbraio Physical activity has systemic effects on the body, affecting almost every organ. It is important not only for general health and wellbeing, but also in the prevention of diseases. The mechanisms behind the therapeutic effects of physical...
Mon Sep 28, 2020 03:00
Climate, Vol. 8, Pages 106: Assessing the Adaptive Capacity of Households to Climate Change in the Central Rift Valley of Ethiopia Climate doi: 10.3390/cli8100106 Authors: Demamu Mesfin Belay Simane Abrham Belay John W. Recha Ute Schmiedel This paper explores the different components of the adaptive capacity of households in the Central Rift Valley (CRV) of Ethiopia and quantifies their relative contributions. The data were derived from a survey of 413 households randomly...
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Diagnostics, Vol. 10, Pages 765: A Multi-Center, Real-Life Experience on Liquid Biopsy Practice for EGFR Testing in Non-Small Cell Lung Cancer (NSCLC) Patients Diagnostics doi: 10.3390/diagnostics10100765 Authors: Francesco Cortiula Giulia Pasello Alessandro Follador Giorgia Nardo Valentina Polo Elisa Scquizzato Alessandro Del Conte Marta Miorin Petros Giovanis Alessandra D’Urso Salvator Girlando Giulio Settanni Vincenzo Picece Antonello Veccia Carla...
Mon Sep 28, 2020 03:00
Diagnostics, Vol. 10, Pages 763: Fuzzy-Inspired Photoplethysmography Signal Classification with Bio-Inspired Optimization for Analyzing Cardiovascular Disorders Diagnostics doi: 10.3390/diagnostics10100763 Authors: Sunil Kumar Prabhakar Harikumar Rajaguru Sun-Hee Kim The main aim of this paper is to optimize the output of diagnosis of Cardiovascular Disorders (CVD) in Photoplethysmography (PPG) signals by utilizing a fuzzy-based approach with classification. The extracted parameters...
Mon Sep 28, 2020 03:00
Diagnostics, Vol. 10, Pages 762: PRINS lncRNA Is a New Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas Diagnostics doi: 10.3390/diagnostics10100762 Authors: Magda Kopczyńska Tomasz Kolenda Kacper Guglas Joanna Sobocińska Anna Teresiak Renata Bliźniak Andrzej Mackiewicz Jacek Mackiewicz Katarzyna Lamperska Numerous studies have shown that human papillomavirus (HPV) infection is one of the important risk factors for...
Mon Sep 28, 2020 03:00
Diagnostics, Vol. 10, Pages 764: A Lateral Flow Immunoassay for the Rapid Identification of CTX-M-Producing Enterobacterales from Culture Plates and Positive Blood Cultures Diagnostics doi: 10.3390/diagnostics10100764 Authors: Sandrine Bernabeu Kayaththiry Caroline Ratnam Hervé Boutal Camille Gonzalez Anaïs Vogel Karine Devilliers Marc Plaisance Saoussen Oueslati Surbhi Malhotra-Kumar Laurent Dortet Nicolas Fortineau Stéphanie Simon Hervé Volland Thierry...
Mon Sep 28, 2020 03:00
Diagnostics, Vol. 10, Pages 761: Combined Immunofluorescence (IFA) and Fluorescence In Situ Hybridization (FISH) Assays for Diagnosing Babesiosis in Patients from the USA, Europe and Australia Diagnostics doi: 10.3390/diagnostics10100761 Authors: Jyotsna S. Shah Eddie Caoili Marie Fe Patton Snehal Tamhankar Mu Mu Myint Akhila Poruri Olivia Mark Richard I. Horowitz Alan D. Ashbaugh Ranjan Ramasamy Apicomplexan parasites of the genus Babesia cause babesiosis...
Mon Sep 28, 2020 03:00
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