Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis

The antiviral effects of IRF-3 are known to involve transcription of interferon stimulated genes as well as inducing apoptosis in infected cells. Sen and colleagues report that these two antiviral pathways mediated by IRF-3 are independent and that the apoptotic pathway is sufficient to inhibit viral pathogenesis

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