The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells

The mechanisms leading to the presence of cytosolic DNA in cancer cells are unknown. Gasser and colleagues find that the DNA structure-specific endonuclease Mus81 promotes the shedding of genomic DNA into the cytosol of prostate cancer cells. Mus81 stimulates STING-dependent DNA sensor pathways and immune rejection of prostate cancer cells.

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