Reproducibility of the Inflammatory Response to Inhaled Endotoxin in Healthy Volunteers

Publication date: Available online 10 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Aaron K. Kobernick, David B. Peden, Haibo Zhou, Qinging Zhou, Madeline Adams Dillon, Neil E. Alexis

Teaser

We describe reproducibility of the inflammatory matrix generated by inhaled endotoxin (LPS) in humans, including sputum neutrophils, interleukin (IL)-1β, IL-6, and IL-8, and demonstrate modification of the inflammatory response based on glutathione-S-transferase mu-1 (GSTM1) genotype.


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