Innate Generation of Thrombin and Intracellular Oxidants in Airway Epithelium by Allergen Der p 1

Publication date: Available online 24 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Jihui Zhang, Jie Chen, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson

Teaser

Innate responses to allergens are key to allergy development, but poorly understood. Unexpectedly, and convergent with TLR3 signaling, Der p 1 directly activates prothrombin and generates intracellular oxidants, suggesting novel innate mechanisms for disease progression.


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