Does Dose to an Oral Mucosa Organ at Risk Predict the Duration of Grade 3 Mucositis after Intensity-modulated Radiotherapy for Oropharyngeal Cancer?

Does Dose to an Oral Mucosa Organ at Risk Predict the Duration of Grade 3 Mucositis after Intensity-modulated Radiotherapy for Oropharyngeal Cancer?

Clin Oncol (R Coll Radiol). 2016 Apr 25;

Authors: Yahya S, Benghiat H, Nightingale P, Tiffany M, Sanghera P, Hartley A

Abstract
Various methods have been described to delineate the oral mucosa organ at risk (OAR), but none has been prospectively verified. This study examined whether dosimetric parameters derived from two different OARs correlated to the duration of acute grade 3 mucositis in patients with oropharyngeal carcinoma. In total, 66 patients were included in this study. The duration of CTCAE version 3 grade 3 mucositis and the duration of strong opiate use were prospectively recorded together with six patient factors. In addition, for each OAR the following dose parameters were derived: mean dose, V55, V50, V45, V40 and V30. No statistically significant correlation of version 3 grade 3 mucositis or duration of strong opiate use was noted with the tested parameters, with the exception of a trend towards significance with pre-treatment weight (P = 0.053) reaching statistical significance on subsequent linear regression. This study failed to show a relationship between dosimetric parameters derived from two oral mucosa OARs and the duration of CTCAE version 3 grade 3 mucositis or the duration of opiate use, potentially suggesting serial rather than parallel radiobiological phenomena. The utility of CTCAE version 4 grade 3 mucositis as an end point requires further investigation, given its potential relationship to pre-treatment weight.

PMID: 27133523 [PubMed - as supplied by publisher]

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