Opposing functions of TSLP-responsive basophils and dendritic cells in a mouse model of atopic dermatitis

Publication date: Available online 4 June 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Christian Schwartz, Joerg U. Eberle, Thomas Hoyler, Andreas Diefenbach, Matthias Lechmann, David Voehringer

Teaser

TSLP promotes inflammation in a mouse model of atopic dermatitis by activating DCs while TSLP-responsive basophils ameliorate pathology. This indicates that DCs rather than basophils should be targeted to improve disease conditions.


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