Trends, Characteristics and Incidence of Anaphylaxis in 2001-2010: A Population Based Study

Publication date: Available online 4 June 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Sangil Lee, Erik P. Hess, Christine Lohse, Waqas Gilani, Alanna M. Chamberlain, Ronna L. Campbell
BackgroundAnaphylaxis is a potentially life-threatening systemic allergic reaction.ObjectiveWe aimed to determine the incidence rate and causes of anaphylaxis during a 10-year period in Olmsted County, Minnesota.MethodsUsing the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, we performed a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed by fitting Poisson regression models.ResultsSix hundred and thirty-one cases of anaphylaxis were identified. Median age was 31 years (interquartile range 19-44). The overall age- and sex-adjusted incidence rate was 42 (95% CI 38.7-45.3) per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period with an average increase of 4.3% per year (P < 0.001). In addition, there was a 9.8% increase per year in the incidence rate for food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0-9 years, venom related anaphylaxis was most common in those 20-39 years of age, and medication-related anaphylaxis was most common in those 30-39 years of age.ConclusionThe overall incidence rate of anaphylaxis was 42 per 100,000 person-years from 2001-2010 in Olmsted County, Minnesota. The incidence of anaphylaxis increased over time, and several inciting triggers were uniquely associated with different age groups.

Teaser

We found an increased incidence of anaphylaxis over time, especially food-related anaphylaxis in a population-based cohort from 2001 to 2010.


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