Tcf1 and Lef1 pack their own HDAC

Nature Immunology 17, 615 (2016). doi:10.1038/ni.3469

Authors: Charles P Ng & Dan R Littman

The transcription factors Tcf1 and Lef1 have intrinsic histone-deacetylase activity that is required for the repression of CD4+ T cell–lineage genes in CD8+ T cells.

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