ILC2s masquerade as ILC1s to drive chronic disease

Nature Immunology 17, 611 (2016). doi:10.1038/ni.3467

Author: Gabrielle T Belz

Tissue-resident innate lymphoid cells (ILCs) perform diverse roles in regulating mucosal homeostasis and inflammation. The transdifferentiation of ILC2s into interferon-γ (IFN-γ)-producing ILC1-like cells generates a highly inflammatory immune cell.

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