Estimation of bone loss biomarkers as a diagnostic tool for peri-implantitis.

Related Articles

Estimation of bone loss biomarkers as a diagnostic tool for peri-implantitis.

J Periodontol. 2014 Nov;85(11):1566-74

Authors: Rakic M, Struillou X, Petkovic-Curcin A, Matic S, Canullo L, Sanz M, Vojvodic D

Abstract
BACKGROUND: The aims of this study are to estimate the profile of bone loss biomarkers in peri-implant tissues and to identify potential prognostic biomarkers of peri-implantitis.
METHODS: Peri-implant crevicular fluid samples collected from 164 participants (52 patients with peri-implantitis, 54 with mucositis, and 58 with healthy peri-implant tissues) were analyzed using enzyme-linked immunosorbent assays to evaluate concentrations of the receptor activator of nuclear factor-κB (RANK), soluble RANK ligand (sRANKL), osteoprotegerin (OPG), cathepsin-K, and sclerostin.
RESULTS: Concentrations of RANK, sRANKL, OPG, and sclerostin were significantly increased in patients with peri-implantitis compared with patients with healthy peri-implant tissues. Comparisons between peri-implantitis and mucositis demonstrated significantly higher values of sclerostin in peri-implantitis samples. Comparisons between mucositis and healthy peri-implant tissues showed significantly increased levels of RANK and cathepsin-K in mucositis.
CONCLUSION: These results are suggestive of a role of sRANKL, OPG, and sclerostin as prognostic biomarkers in peri-implantitis.

PMID: 24878328 [PubMed - indexed for MEDLINE]

from #ENT via xlomafota13 on Inoreader http://ift.tt/27AL3r5
via IFTTT