Early Life Rhinovirus Wheezing, Allergic Sensitization and Asthma Risk at Adolescence

Publication date: Available online 10 May 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Frederick J. Rubner, Daniel J. Jackson, Michael D. Evans, Ronald E. Gangnon, Christopher J. Tisler, Tressa E. Pappas, James E. Gern, Robert F. Lemanske
BackgroundEarly life rhinovirus (RV) wheezing illnesses and aeroallergen sensitization increase risk of asthma at school age. Whether these remain risk factors for the persistence of asthma out to adolescence is not established.ObjectiveTo define the relationships among specific viral illnesses and the type and timing of aeroallergen sensitization with the persistence of asthma into adolescence.Methods217 children were followed prospectively from birth to age 13 years. The etiology and timing of viral wheezing illnesses during the first 3 years of life were assessed along with patterns of allergen sensitization. The associations between viral wheezing illnesses, presence and pattern of aeroallergen sensitization and asthma diagnosis at 13 years of age were evaluated.ResultsWhen adjusted for all viral etiologies, wheezing with RV [odds ratio (OR) = 3.3, 95% CI 1.5-7.1], but not respiratory syncytial virus (RSV) [OR = 1.0, 95% CI 0.4-2.3], was associated with asthma at age 13 years. Age of aeroallergen sensitization also influenced asthma risk; 65% of children sensitized by age 1 year had asthma at age 13 years, compared to 40% of children not sensitized at age 1 but sensitized by age 5, and 17% of children not sensitized at age 5. Early life aeroallergen sensitization and RV wheezing had additive effects on asthma risk at adolescence.ConclusionIn a high-risk birth cohort, the persistence of asthma at 13 years of age was most strongly associated with outpatient wheezing illnesses with RV and aeroallergen sensitization in early life.

Teaser

Rhinovirus (RV) wheezing illnesses and aeroallergen sensitization in early childhood are associated with an increased risk of asthma in adolescence.


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