Clinical Evaluation of Salivary Carbohydrate Antigen 125 and Leptin in Controls and Parotid Tumours

Abstract

Objectives

We determined the correlation between saliva and serum for CA125 and leptin, and evaluated their clinical screening potential for parotid tumours.

Subjects and Methods

Serum, acid-stimulated bilateral parotid saliva and chewing-stimulated whole saliva were collected and measured the levels of CA125 and leptin with electrochemiluminescence immunoassay and enzyme linked immunosorbent assay for healthy controls and patients with unilateral parotid tumour. Intra- and inter-group comparisons were made among them. Correlations and Receiver Operating Curve analyses were also conducted.

Results

There was no correlation between salivary and serum CA125 (r = -0.157 – 0.265, P > 0.05), while significant correlation was found for leptin (r = 0.219 – 0.761, P < 0.05). Leptin levels in tumour parotid saliva and CA125 levels in whole saliva were elevated significantly (P < 0.001) and showed screening potential for parotid tumours. Salivary and serum leptin levels were significantly higher in women than in men (P < 0.001).

Conclusions

Salivary CA125 might originate primarily from salivary gland and tumour rather than from blood, while salivary leptin might originate from both blood and salivary gland. Multiple sources might contribute to the significantly elevated CA125 in whole saliva. Whole saliva CA125 and parotid saliva leptin reflected the occurrence of parotid tumours, while serum CA125 and leptin did not. Salivary CA125 and leptin could not distinguish malignant parotid tumours. When detecting leptin level, the influence of subjects' sex must be considered.

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