Significance of combined preoperative serum Alb and dNLR for diagnosis of pancreatic cancer.

Significance of combined preoperative serum Alb and dNLR for diagnosis of pancreatic cancer.

Future Oncol. 2018 Jan 17;:

Authors: Liu JX, Li A, Zhou LY, Liu XF, Wei ZH, Wang XZ, Ying HQ

Abstract
AIM: To investigate diagnostic value of preoperative inflammatory biomarkers in pancreatic cancer (PCC).
MATERIALS & METHODS: Preoperative circulating Alb/Fib ratio, neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte ratio and lymphocyte/monocyte ratio were detected and calculated in 226 PCC individuals, 232 healthy controls and 142 additional cancer controls. Receiver-operating characteristic curve and area under the curve (AUC) were used to evaluate the diagnostic efficacy of PCC.
RESULTS: Combined circulating dNLR and Alb could effectively improve the diagnosis of PCC (AUC = 0.931), single dNLR could distinguish early-stage PCC and the disease from healthy controls (AUC = 0.895) and additional cancer controls (AUC = 0.794).
CONCLUSION: Circulating dNLR was an effective biomarker for diagnosis and identification of early-stage PCC. Combined dNLR and Alb could improve the diagnostic efficacy of the disease.

PMID: 29338337 [PubMed - as supplied by publisher]

from #PM All via ola Kala on Inoreader http://ift.tt/2Bdd5fP