A retrospective case control analysis of the efficacy of Gardasil® vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx.

A retrospective case control analysis of the efficacy of Gardasil® vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx.

Clin Otolaryngol. 2018 Jan 30;:

Authors: Milner TD, Harrison A, Montgomery J, MacGregor FB, Buchanan MA, MacKenzie K

Abstract
Recurrent respiratory papillomatosis (RRP) of the larynx represents a significant disease burden to patients and the healthcare system The use of HPV 6/11/16/18 vaccination (Gardasil® ) has previously been thought to impact on disease burden in patients with RRP. Gardasil® vaccination did not impact on the number of endolaryngeal surgical procedures required, the interval between procedures, or the number of patients who achieved disease remission in comparison to a control cohort. This study indicates Gardasil® vaccination does not appear to have any effect on disease burden in patients with RRP. The use of a control cohort profiles the natural progression of RRP. This article is protected by copyright. All rights reserved.

PMID: 29380936 [PubMed - as supplied by publisher]

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