Enrolling children with acute lymphoblastic leukaemia on a clinical trial improves event-free survival: a population-based study.
Br J Cancer. 2018 Jan 30;:
Authors: Strahlendorf C, Pole JD, Barber R, Dix D, Kulkarni K, Martineau E, Randall A, Stammers D, Strother D, Truong TH, Sung L
Abstract
BACKGROUND: The objectives of this study were to describe the impact of trial enrollment at diagnosis on event-free and overall survival in paediatric acute lymphoblastic leukaemic (ALL) using a population-based approach.
METHODS: We conducted a retrospective cohort study that included children newly diagnosed with ALL between 1 and 14 years of age. The data source was the Cancer in Young People in Canada (CYP-C) national paediatric cancer population-based database. We conducted univariate and multiple Cox proportional hazards models.
RESULTS: There were 2569 children with ALL; 1408 (54.8%) were enrolled on a clinical trial at initial diagnosis. Event-free survival at 5 years was 89.8%±0.9 vs 84.1%±1.2. (P<0.0001) for those enrolled and not enrolled on a clinical trial, respectively. Overall survival at 5 years was higher for those enrolled (94.1%±0.7) vs not enrolled (90.5%±1.0; P=0.001). In a model that adjusted for demographic, leukaemic and socioeconomic factors, enrollment on trials was significantly associated with better event-free survival (hazard ratio (HR) 0.67, 95% confidence interval (CI) 0.47-0.95; P=0.023), but not overall survival (HR 0.69, 95% CI 0.44-1.08; P=0.102).
CONCLUSIONS: Event-free survival was significantly better in children with ALL enrolled on a clinical trial. Future research should identify barriers to clinical trial enrollment for children with ALL.British Journal of Cancer advance online publication, 30 January 2018; doi:10.1038/bjc.2017.462 www.bjcancer.com.
PMID: 29381687 [PubMed - as supplied by publisher]
from #PM All via ola Kala on Inoreader http://ift.tt/2rVq3zt
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου