Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review.

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Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review.

Tissue Eng Part B Rev. 2016 Dec;22(6):421-429

Authors: Wrona EA, Peng R, Amin MR, Branski RC, Freytes DO

Abstract
The vocal folds (VFs) are exposed to a number of injurious stimuli that frequently lead to aberrant structural alterations and altered biomechanical properties that clinically manifest as voice disorders. Therapies to restore both structure and function of this delicate tissue are ideal. However, such methods have not been adequately developed. Our group and others hypothesize that tissue engineering and regenerative medicine approaches, previously described for other tissue systems, hold significant promise for the VFs. In this review, we explore the concept of tissue engineering as it relates to the VFs, as well as recent studies employing both naturally and synthetically derived biomaterials, including those from laryngeal and nonlaryngeal sources, in combination with stem cells for a tissue-engineered approach to VF repair.

PMID: 27316784 [PubMed - indexed for MEDLINE]

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