Regulation of Autophagy by Hepatitis C Virus for Its Replication.

Regulation of Autophagy by Hepatitis C Virus for Its Replication.

DNA Cell Biol. 2018 Jan 19;:

Authors: Wang L, Ou JJ

Abstract
Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in recent years indicated that this virus could regulate this cellular pathway and use it to enhance its replication. HCV could temporally control the autophagic flux and use the autophagic membranes for the assembly of its RNA replication complex. In this report, we will discuss the biogenesis of autophagosomes induced by HCV and how HCV uses this autophagic pathway for its RNA replication.

PMID: 29350547 [PubMed - as supplied by publisher]

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