Is Psychiatric Depression a Presenting Neurologic Sign of Meningioma? A Critical Review of the Literature with Causative Etiology.

Is Psychiatric Depression a Presenting Neurologic Sign of Meningioma? A Critical Review of the Literature with Causative Etiology.

World Neurosurg. 2018 Jan 19;:

Authors: Kessler RA, Loewenstern J, Kohli K, Shrivastava RK

Abstract
Benign meningiomas constitute 80-90% of all meningiomas, and represent the most common type of central nervous system (CNS) tumor in adults. The vast majority of meningiomas are minimally symptomatic or asymptomatic early in their onset and thereby can often result in delayed diagnosis. Early diagnosis of meningioma is critical as it can maximize treatment options and improve outcomes and survival. While seizures and focal neurological deficits are considered to be the most prevalent symptoms, depression may also be an important and significant sign. A subtle neurologic depression may be an even early presenting sign of meningioma and may precede more traditional presenting symptoms. We performed a comprehensive literature review that analyzes the results of prospective studies and case reports on this topic, and the findings show evidence to suggest that depression may be correlated with meningioma presentation. Its prevalence is possibly increased with an anterior location of the tumor. For patients who exhibit nuances of depression without a history of psychiatric illness, an index of suspicion for meningioma may be warranted.

PMID: 29360583 [PubMed - as supplied by publisher]

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