A case of molecularly profiled extraneural medulloblastoma metastases in a child.

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A case of molecularly profiled extraneural medulloblastoma metastases in a child.

BMC Med Genet. 2018 Jan 17;19(1):10

Authors: Mobark NA, Al-Harbi M, Mosleh O, Santagata S, Snuderl M, Abedalthagafi M

Abstract
BACKGROUND: Extraneural metastases are relatively rare manifestations of medulloblastoma.
CASE PRESENTATION: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options.
CONCLUSION: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.

PMID: 29343221 [PubMed - in process]

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