In allergic rhinitis, work, classroom and activity impairments are weakly related to other outcome measures

Abstract

Background

The impact of grass-pollen-induced allergic rhinoconjunctivitis (AR) on classroom/work productivity and activities can be assessed with a specific instrument: the Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific (WPAI-AS). The present study evaluated the relationships between the WPAI-AS and other outcome measures in AR.

Methods

Adolescents (aged 12–17) and adults (aged 18–65) consulting specialists for AR were enrolled in a four-week, multicentre, observational study. The management of AR was left to the physicians' discretion. Participants regularly rated the WPAI-AS, their symptoms (using the Rhinoconjunctivitis Total Symptom Score (RTSS) and a 0-to-100 mm visual analogue scale (VAS)), and quality of life (according to the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)).

Results

247 adolescents and 292 adults showed similar baseline impairments in classroom/work productivity and activities other than work. In both age groups, the WPAI-AS scores were moderately correlated with the RQLQ score and, to a lesser extent, with the VAS score and the RTSS. A multiple regression analysis indicated that the RQLQ score was a weak but statistically significant predictor of both impaired work/classroom productivity and daily activities. A 50 mm VAS cut-off categorized patients in whom AR had the greatest impact on productivity.

Conclusions

Grass-pollen-induced AR impairs work/classroom and daily activity to a similar extent in adults and adolescents. The weak-to-moderate correlations with AR symptom scores and quality of life scores suggest that a specific tool (such as the WPAI-AS) should be used to assess AR's impact on word/classroom productivity and daily activities.

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