Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 T Cell-Mediated Immunity in Colorectal Cancer

All-trans-retinoic acid (atRA) plays crucial roles in shaping intestinal immunity. Bhattacharya et al. show that, in the context of colon cancer, microbiota-induced intestinal inflammation alters atRA metabolism, leading to a colonic atRA deficit and exacerbation of colon carcinogenesis. atRA supplementation ameliorates colon carcinogenesis in a CD8+ T cell-dependent manner.

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