Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

The role of hematopoietic stem cells (HSCs) in steady-state hematopoiesis remains controversial. Here, Sawai et al. use lineage tracing to reveal a major contribution of HSCs to all blood cell lineages, including myeloid cells and lymphocytes, throughout adult life.

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