Central and peripheral nervous system excitability in restless legs syndrome

• Restless legs syndrome (RLS) should be regarded as a complex neurophysiological network disorder.• Electrophysiology can probe the excitability and indirectly the neurochemistry of RLS.• Cortical−spinal generators are likely hyperexcitable and/or less inhibited in RLS.• Neurophysiology can contribute to the deciphering of RLS pathophysiology.

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