Unchaining NK cell–mediated anticancer immunosurveillance

Nature Immunology 17, 746 (2016). doi:10.1038/ni.3471

Authors: Laurence Zitvogel & Guido Kroemer

In natural killer (NK) cells, CIS restrains a signaling pathway elicited by interleukin 15 (IL-15) that leads to activation of the kinase JAK1. Removal of CIS from NK cells increases their capacity to reduce the metastatic dissemination of breast cancer and melanoma in mice.

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