Τρίτη 21 Ιουνίου 2016

Risk and prognostic factors for pneumonia and choking amongst Parkinson's disease patients with dysphagia.

Risk and prognostic factors for pneumonia and choking amongst Parkinson's disease patients with dysphagia.

Parkinsonism Relat Disord. 2016 May 30;

Authors: Goh KH, Acharyya S, Ng SY, Boo JP, Kooi AH, Ng HL, Li W, Tay KY, Au WL, Tan LC

Abstract
OBJECTIVE: To evaluate the time to hospitalisation and baseline factors associated with pneumonia/choking in Parkinson's Disease (PD) patients.
BACKGROUND: Although dysphagia and pneumonia are common problems in PD, scarce research has been performed.
METHODS: A total of 194 PD patients who underwent a VFS evaluation were retrospectively selected. The mode of feeding and admissions for pneumonia/choking were analyzed. Baseline clinical and demographic variables were compared between feeding groups. Kaplan-Meier survival analysis was performed to estimate time to pneumonia/choking. Clinical variables significantly associated with pneumonia/choking free survival were identified using Cox regression.
RESULTS: Hospitalisation for pneumonia/choking occurred in 89 out of 194 patients, with the highest admission rate in rejected enteral feeding group (66.7%), followed by enteral feeding (61.8%) and oral feeding (38.8%) groups. The estimates of median time to event were 11, 14, and 47 months for rejected enteral feeding, enteral and oral feeding groups respectively (log-rank test p < 0.001). The rejected enteral feeding group had the highest risk of pneumonia/choking (HR 4.61, 95%CI:2.33-9.08, p < 0.001), followed by enteral feeding group (HR 2.29, 95%CI:1.25-4.19, p = 0.007), when compared to oral feeding group after adjusting for possible confounders. A stepwise Cox regression showed that the rejected enteral feeding (HR 4.89, 95%CI:2.19-10.88, p < 0.001), enteral mode of feeding (HR 2.43, 95%CI:1.11-5.32, p = 0.026), and Charlson weighted index of co-morbidity (HR 1.27, 95%CI:1.03-1.58, p = 0.028) were independently associated with higher hazard of pneumonia/choking.
CONCLUSIONS: Compliance to feeding recommendations is important to reduce the risk of hospitalisation for pneumonia/choking. The recommended mode of feeding and comorbidity index was significantly associated with pneumonia/choking risk.

PMID: 27321989 [PubMed - as supplied by publisher]



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