Δευτέρα 6 Ιουνίου 2016

Chemerin and interleukin-6 levels in obese individuals following periodontal treatment

Abstract

Objective

To investigate changes in the levels of gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) in both obese/non-obese individuals with periodontitis following non-surgical periodontal therapy.

Methods

Individuals (n=80) were split into four groupings according to periodontal/anthropometric parameters, these were a) periodontal-healthy without obesity; b) chronic periodontitis (CP) without obesity; c) periodontal-healthy with obesity; and d) CP with obesity. Individuals with periodontitis were treated with non-surgical periodontal therapy. Both GCF sampling procedures and clinical periodontal measures were performed prior to treatment and six weeks thereafter. Enzyme-linked immunosorbent assay was utilized to measure both chemerin and IL-6 levels.

Results

Greater values for chemerin and IL-6 were observed in obese individuals compared to their non-obese controls, and in individuals with CP compared to their periodontal-healthy controls (P<0.008), which decreased following therapy (P<0.05). A positive correlation was found between chemerin and IL-6 in obese groups (P<0.05). A comprehensive overview of all groups showed a statistically significant positive correlation among chemerin, along with IL-6, WHR, BMI, as well as CAL (P<0.05).

Conclusion

It could be concluded that chemerin levels may act as both diagnostic and prognostic indicators. Chemerin may also play an integral part in the pathologic mechanisms that relate adipokines to both periodontal disease and obesity.

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