TGF-β1-induced transcription factor networks in Langerhans cell development and maintenance

Abstract

Langerhans cells (LC) represent a specialized subset of evolutionarily conserved dendritic cells (DC) that populate stratified epithelial tissues, which are essential for the induction of skin and mucosal immunity and tolerance, including allergy. TGF-β1 has been confirmed to be a predominant factor involved in LC development. Despite great advances in the understanding of LC ontogeny and diverse replenishment patterns, the underlying molecular mechanisms remain elusive. This review focuses on the recent discoveries in TGF-β1-mediated LC development and maintenance, with special attention to the involved transcription factors and related regulators.

This article is protected by copyright. All rights reserved.

from #ENT via xlomafota13 on Inoreader http://ift.tt/1Qx0Cap
via IFTTT