MicroRNAs in Oral lichen Planus and potential miRNA-mRNA pathogenesis with essential cytokines: A Review

Publication date: Available online 31 March 2016
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Hui Ma, Yuanqin Wu, Huamei Yang, Jiajia Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Lu Jiang, Qianming Chen
Oral lichen planus (OLP) is a potentially premalignant condition with an unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, can act as critical players in the immunopathogenesis of OLP. MicroRNAs (miRNAs) are closely correlated with cytokines in various inflammation-related diseases. In patients with OLP, miRNA-146a and miRNA-155 are increased in peripheral blood mononuclear cells, and numerous miRNAs have been shown to exhibit altered expression profiles in lesions. While the miRNA-mRNA network is thought to be involved in the development of OLP, in-depth studies are lacking. Here, we summarize current data on the mechanisms of action of miRNAs regulating typical cytokines in OLP, including interleukin (IL)-10, IL-17, IL-22, IFN-γ, and TNF-α, to study the genetic basis of the pathogenesis of OLP and to provide prospects of therapy.



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