Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

B cell selection and affinity maturation in germinal centers (GCs) elicited by complex antigens are not well studied. Kelsoe and colleagues demonstrate that affinity maturation in GCs is accompanied by increased clonal diversity and large variances in inter- and intraclonal BCR avidities in response to anthrax protective antigen and influenza hemagglutinin.

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