Τετάρτη 25 Απριλίου 2018

Evaluating Multipulse Integration as a Neural-Health Correlate in Human Cochlear-Implant Users: Relationship to Psychometric Functions for Detection

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Evaluating Multipulse Integration as a Neural-Health Correlate in Human Cochlear-Implant Users: Relationship to Psychometric Functions for Detection

Trends Hear. 2017 01;21:2331216517690108

Authors: Zhou N, Dong L

Abstract
In electrical hearing, multipulse integration (MPI) describes the rate at which detection threshold decreases with increasing stimulation rate in a fixed-duration pulse train. In human subjects, MPI has been shown to be dependent on the psychophysically estimated spread of neural excitation at a high stimulation rate, with broader spread predicting greater integration. The first aim of the present study was to replicate this finding using alternative methods for measuring MPI and spread of neural excitation. The second aim was to test the hypothesis that MPI is related to the slope of the psychometric function for detection. Specifically, a steep d' versus stimulus level function would predict shallow MPI since the amount of current reduction necessary to compensate for an increase in stimulation rate to maintain threshold would be small. The MPI function was measured by obtaining adaptive detection thresholds at 160 and 640 pulses per second. Spread of neural excitation was measured by forward-masked psychophysical tuning curves. All psychophysical testing was performed in a monopolar stimulation mode (MP 1 + 2). Results showed that MPI was correlated with the slopes of the tuning curves, with broader tuning predicting steeper MPI, confirming the earlier finding. However, there was no relationship between MPI and the slopes of the psychometric functions. These results suggest that a broad stimulation of the cochlea facilitates MPI. MPI however is not related to the estimated neural excitation growth with current level near the behavioral threshold, at least in monopolar stimulation.

PMID: 28150534 [PubMed - indexed for MEDLINE]



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