Hypoxia and Acidosis: Immune Suppressors and Therapeutic Targets.

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Hypoxia and Acidosis: Immune Suppressors and Therapeutic Targets.

Immunology. 2018 Feb 27;:

Authors: Damgaci S, Ibrahim-Hashim A, Enriquez-Navas PM, Pilon-Thomas S, Guvenis A, Gillies RJ

Abstract
Due to imbalances between vascularity and cellular growth patterns, the tumor microenvironment harbors multiple metabolic stressors including hypoxia and acidosis, which have significant influence on remodeling both tumor and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance. Understanding these effects and characterizing the pathways involved can identify new targets for therapy and may redefine our understanding of traditional anti-tumor therapies. In this review, the effects of hypoxia and acidosis on tumor immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions discussed. This article is protected by copyright. All rights reserved.

PMID: 29485185 [PubMed - as supplied by publisher]

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