Efficacy and safety of the trastuzumab biosimilar candidate CT-P6.

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Efficacy and safety of the trastuzumab biosimilar candidate CT-P6.

Future Oncol. 2018 Feb 27;:

Authors: Esteva FJ, Saeki T, Kim H, Stebbing J

Abstract
Trastuzumab is an anti-HER2 monoclonal antibody indicated for the treatment of HER2-overexpressing breast and gastric cancers. Despite its clinical efficacy, access to the biological drug can be limited due to its relatively high price, especially in low-income countries. CT-P6 (Herzuma®) is a biosimilar candidate of originator or 'reference' trastuzumab, which may offer an alternative, more cost-effective treatment option. This article reviews the unmet needs of patients eligible to receive reference trastuzumab and the potential place of a trastuzumab biosimilar within the market. The review also summarizes the available clinical evidence supporting the biosimilarity of CT-P6 and reference trastuzumab with respect to pharmacokinetics, efficacy, safety and immunogenicity.

PMID: 29482364 [PubMed - as supplied by publisher]

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