Oral surgery in patients with Glanzmann thrombasthenia: a case series

Publication date: Available online 6 October 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Eleonora Segna, Andrea Artoni, Raffaele Sacco, Aldo Bruno Giannì
Glanzmann thrombasthenia is a severe defect of platelet function caused by an inherited deficiency or dysfunction of the glycoprotein IIb/IIIa complex (GPIIb/IIIa), the platelet fibrinogen receptor. Patients diagnosed with Glanzmann thrombasthenia have a lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis. Surgery is usually very challenging, requiring close co-operation between surgeons, hematologists and anesthesiologists. For anatomical reasons, oral surgery is particularly difficult due to the inherent risk of hemorrhage and the difficulty in achieving local hemostasis. In this paper we describe three successful cases of oral surgery in patients with Glanzmann thrombasthenia and report the surgical and hematological management of each case.



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