Lactobacillus reuteri DSM 17938 plus vitamin D3 as ancillary treatment in allergic children with asthma

Asthma is a heterogeneous disease usually characterized by chronic airway inflammation.1 Allergy and asthma prevalence has significantly increased worldwide during the past decades,2 and the hygiene hypothesis suggests that reduced exposure to microbial agents could increase the risk of allergic diseases.3 This theory has been recently revisited with an emphasis on the role of microbiota dysbiosis that promotes impaired immunologic tolerance to allergens.4 In addition, vitamin D3 deficiency has been associated with asthma and allergy inception and worsening.

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