Colon Cancer in the Land of NOD: NLRX1 as an Intrinsic Tumor Suppressor

Publication date: Available online 21 July 2016
Source:Trends in Immunology
Author(s): Andrea Lei, Kevin J. Maloy
Although best known for inducing inflammasome formation and pyroptosis in myeloid cells, increasing evidence highlights additional roles for Nod-like receptors (NLR) in nonhematopoietic cells. Two recent studies demonstrate that NLRX1 functions as an intrinsic tumor suppressor in intestinal epithelial cells (IEC), by regulating their responses to proliferative signals following intestinal injury.



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