Osteonecrosis of the Jaw in the Absence of Antiresorptive or Anti-angiogenic Exposure: A Series of Six Cases

Publication date: Available online 30 July 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Tara L. Aghaloo, Sotirios Tetradis
Medication related osteonecrosis of the jaws (MRONJ) is a well-described complication of antiresorptive and antiangiogenic medications. Although osteonecrosis can be associated with other inciting events and medications such as trauma, infection, steroids, chemotherapy, and coagulation disorders, these are rarely reported in the literature. Since the continued development and clinical use of new biologic medications for diseases such as cancer and rheumatoid arthritis, it is important to continue to evaluate their effects on the oral cavity. Here, we report a six case series of MRONJ associated with medications other than antiresorptives or antiangiogenics. The degree of risk for osteonecrosis in patients taking these new classes of drugs is uncertain but warrants awareness and monitoring.



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