Our back cover features Luxol Fast Blue and H&E stainings of lumbar spinal cord from galectin-1 deficient (Lgals1−/−) mice. Mice were immunized to induce experimental autoimmune encephalomyelitis (EAE) and treated with intravenous autoantigen. Demyelination and inflammation are apparent in the white matter of Lgals1−/− mice but is not present in C57BL/6 EAE mice treated with intravenous autoantigen. The image is taken from Mari et al. (pp. 1783–1796), where the authors present for the first time a role for galectin-1 in the induction of intravenous tolerance, providing new insights into the role of galectin-1 in a model of CNS autoimmune inflammation.
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