Treating Pressure Ulcers with Clostridial Collagenase Ointment: Results From the US Wound Registry

ABSTRACT

We assessed the clinical effectiveness of clostridial collagenase ointment as an adjunct to selective debridement compared with selective debridement alone for the management of stage IV pressure ulcers in the hospital outpatient department setting. Outcomes data were derived from retrospective de-identified electronic medical records from 2007–2013 using the United States Wound Registry. A propensity score method was used to adjust for selection bias and to test for treatment effect between pressure ulcers treated with clostridial collagenase ointment plus selective debridement versus selective debridement alone. A total of 337 clostridial collagenase ointment and 336 non-clostridial collagenase ointment stage IV pressure ulcers were identified. The proportion of wounds closed at any time (e.g., at 1 year or 2 years) was 2 times greater for stage IV pressure ulcers treated with clostridial collagenase ointment compared with those not treated with clostridial collagenase ointment. Kaplan-Meier analysis showed that time to wound closure at 1 year was significantly faster for pressure ulcers treated with clostridial collagenase ointment versus pressure ulcers not treated with clostridial collagenase ointment. Among those with 5 or more clostridial collagenase ointment applications or selective debridement treatments, significantly more clostridial collagenase ointment–treated pressure ulcers were closed at 1 or 2 years than non-clostridial collagenase ointment–treated pressure ulcers. Clostridial collagenase ointment as an adjunct to selective debridement improved clinical outcomes and provided faster rates of closure of stage IV pressure ulcers relative to selective debridement alone. This article is protected by copyright. All rights reserved.

from #ENT via xlomafota13 on Inoreader http://ift.tt/295Ot0l
via IFTTT