Massive Craniofacial Gorham Disease Treated Successfully by Cisplatin and 5-Fluorouracil with Ten Years of Follow Up: A Case Report and Literature Review

Publication date: Available online 26 March 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Ibrahim Saeed Gataa, Noroz Hama R. Nader, Dastan T. Abdallah
Gorham disease (GD) is a rare osteolytic condition of unknown etiology, which causes spontaneous, progressive bone resorption. The maxillofacial area is one of the regions most frequently involved in this disease. This syndrome is characterized by its aggressiveness and rarity; therefore, the treatment modalities remain controversial, and there is no specific treatment method that has been proven to be effective. This report describes a case of Gorham diseases with massive craniofacial bones involvement, being treated effectively using a combination of 5-fluorouracil and cisplatin, with ten years of follow-up.



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